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[[Image:1ks3.png|left|200px]]


{{STRUCTURE_1ks3|  PDB=1ks3  |  SCENE=  }}
==METHIONINE CORE MUTANT OF T4 LYSOZYME==
 
<StructureSection load='1ks3' size='340' side='right'caption='[[1ks3]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
===METHIONINE CORE MUTANT OF T4 LYSOZYME===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ks3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KS3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12646375}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ks3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ks3 OCA], [https://pdbe.org/1ks3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ks3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ks3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ks3 ProSAT]</span></td></tr>
[[1ks3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KS3 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1ks3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ks3 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012646375</ref><references group="xtra"/>
__TOC__
[[Category: Enterobacteria phage t4]]
</StructureSection>
[[Category: Lysozyme]]
[[Category: Escherichia virus T4]]
[[Category: Baase, W A.]]
[[Category: Large Structures]]
[[Category: Busam, R D.]]
[[Category: Baase WA]]
[[Category: Gassner, N C.]]
[[Category: Busam RD]]
[[Category: Lindstrom, J D.]]
[[Category: Gassner NC]]
[[Category: Matthews, B W.]]
[[Category: Lindstrom JD]]
[[Category: Mooers, B H.]]
[[Category: Matthews BW]]
[[Category: Quillin, M L.]]
[[Category: Mooers BH]]
[[Category: Weaver, L H.]]
[[Category: Quillin ML]]
[[Category: Hydrolase]]
[[Category: Weaver LH]]
[[Category: Methionine core mutant]]
[[Category: Protein engineering]]
[[Category: Protein folding]]
[[Category: T4 lysozyme]]

Latest revision as of 10:27, 14 February 2024

METHIONINE CORE MUTANT OF T4 LYSOZYMEMETHIONINE CORE MUTANT OF T4 LYSOZYME

Structural highlights

1ks3 is a 1 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.16Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

1ks3, resolution 2.16Å

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