1kqo: Difference between revisions

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-{{Seed}}
-[[Image:1kqo.png|left|200px]]
-<!--
+==Crystal structure of NMN/NaMN adenylyltransferase complexed with deamido-NAD==
-The line below this paragraph, containing "STRUCTURE_1kqo", creates the "Structure Box" on the page.
+<StructureSection load='1kqo' size='340' side='right'caption='[[1kqo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1kqo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DND:NICOTINIC+ACID+ADENINE+DINUCLEOTIDE'>DND</scene></td></tr>
-{{STRUCTURE_1kqo|  PDB=1kqo  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kqo OCA], [https://pdbe.org/1kqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kqo RCSB], [https://www.ebi.ac.uk/pdbsum/1kqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kqo ProSAT]</span></td></tr>
+</table>
-===Crystal structure of NMN/NaMN adenylyltransferase complexed with deamido-NAD===
+== Disease ==
+[https://www.uniprot.org/uniprot/NMNA1_HUMAN NMNA1_HUMAN] Defects in NMNAT1 are the cause of Leber congenital amaurosis 9 (LCA9) [MIM:[https://omim.org/entry/608553 608553]. A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.<ref>PMID:22842230</ref> <ref>PMID:22842231</ref> <ref>PMID:22842229</ref> <ref>PMID:22842227</ref>
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/NMNA1_HUMAN NMNA1_HUMAN] Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.<ref>PMID:17402747</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_11788603}}, adds the Publication Abstract to the page
+== Evolutionary Conservation ==
-(as it appears on PubMed at http://www.pubmed.gov), where 11788603 is the PubMed ID number.
+[[Image:Consurf_key_small.gif|200px|right]]
--->
+Check<jmol>
-{{ABSTRACT_PUBMED_11788603}}
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/1kqo_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-KQO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQO OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==Reference==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kqo ConSurf].
-Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin., Zhou T, Kurnasov O, Tomchick DR, Binns DD, Grishin NV, Marquez VE, Osterman AL, Zhang H, J Biol Chem. 2002 Apr 12;277(15):13148-54. Epub 2002 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11788603 11788603]
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Nicotinamide-nucleotide adenylyltransferase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Binns DD]]
-[[Category: Binns, D D.]]
+[[Category: Grishin NV]]
-[[Category: Grishin, N V.]]
+[[Category: Kurnasov O]]
-[[Category: Kurnasov, O.]]
+[[Category: Marquez VE]]
-[[Category: Marquez, V E.]]
+[[Category: Osterman AL]]
-[[Category: Osterman, A L.]]
+[[Category: Tomchick DR]]
-[[Category: Tomchick, D R.]]
+[[Category: Zhang H]]
-[[Category: Zhang, H.]]
+[[Category: Zhou T]]
-[[Category: Zhou, T.]]
-[[Category: Nucleotidyltransferase superfamily]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 10:47:14 2008''