1kqf: Difference between revisions

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[[Image:1kqf.png|left|200px]]


{{STRUCTURE_1kqf|  PDB=1kqf  |  SCENE=  }}
==FORMATE DEHYDROGENASE N FROM E. COLI==
 
<StructureSection load='1kqf' size='340' side='right'caption='[[1kqf]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
===FORMATE DEHYDROGENASE N FROM E. COLI===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kqf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQF FirstGlance]. <br>
{{ABSTRACT_PUBMED_11884747}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MO:MOLYBDENUM(VI)+ION'>6MO</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kqf OCA], [https://pdbe.org/1kqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kqf RCSB], [https://www.ebi.ac.uk/pdbsum/1kqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kqf ProSAT]</span></td></tr>
[[1kqf]] is a 3 chain structure of [[Formate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQF OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FDNG_ECOLI FDNG_ECOLI] Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar).<ref>PMID:11884747</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/1kqf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kqf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Formate dehydrogenase|Formate dehydrogenase]]
*[[Formate dehydrogenase 3D structures|Formate dehydrogenase 3D structures]]
*[[Selenocysteine|Selenocysteine]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:011884747</ref><references group="xtra"/>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Formate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Byrne, B.]]
[[Category: Byrne B]]
[[Category: Iwata, S.]]
[[Category: Iwata S]]
[[Category: Jormakka, M.]]
[[Category: Jormakka M]]
[[Category: Tornroth, S.]]
[[Category: Tornroth S]]
[[Category: Anaerobic]]
[[Category: Dehydrogenase]]
[[Category: Fe4s4]]
[[Category: Formate]]
[[Category: Integral membrane protein]]
[[Category: Iron sulfur cluster]]
[[Category: Mgd]]
[[Category: Molybdenum]]
[[Category: Molybdopterin]]
[[Category: Molybdopterin guanine dinucleotide]]
[[Category: Mpt]]
[[Category: Oxidoreductase]]
[[Category: Secy]]
[[Category: Selenium]]
[[Category: Selenocysteine]]

Latest revision as of 10:26, 14 February 2024

FORMATE DEHYDROGENASE N FROM E. COLIFORMATE DEHYDROGENASE N FROM E. COLI

Structural highlights

1kqf is a 3 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FDNG_ECOLI Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Jormakka M, Tornroth S, Byrne B, Iwata S. Molecular basis of proton motive force generation: structure of formate dehydrogenase-N. Science. 2002 Mar 8;295(5561):1863-8. PMID:11884747 doi:10.1126/science.1068186

1kqf, resolution 1.60Å

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