1kph: Difference between revisions

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-[[Image:1kph.png|left|200px]]
-{{STRUCTURE_1kph|  PDB=1kph  |  SCENE=  }}
+==Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB==
+<StructureSection load='1kph' size='340' side='right'caption='[[1kph]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1kph]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KPH FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11756461}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10A:DIDECYL-DIMETHYL-AMMONIUM'>10A</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kph OCA], [https://pdbe.org/1kph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kph RCSB], [https://www.ebi.ac.uk/pdbsum/1kph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kph ProSAT], [https://www.topsan.org/Proteins/TBSGC/1kph TOPSAN]</span></td></tr>
-[[1kph]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPH OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CMAS1_MYCTU CMAS1_MYCTU] Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:7592990</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/1kph_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kph ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Fatty acid synthase|Fatty acid synthase]]
+*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:011756461</ref><ref group="xtra">PMID:012462144</ref><references group="xtra"/>
+__TOC__
-[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Glickman, M S.]]
+[[Category: Glickman MS]]
-[[Category: Huang, C C.]]
+[[Category: Huang C-C]]
-[[Category: Jacobs, W R.]]
+[[Category: Jacobs Jr WR]]
-[[Category: Sacchettini, J C.]]
+[[Category: Sacchettini JC]]
-[[Category: Smith, C V.]]
+[[Category: Smith CV]]
-[[Category: TBSGC, TB Structural Genomics Consortium.]]
-[[Category: Mixed alpha beta fold]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-[[Category: Tb structural genomics consortium]]
-[[Category: Tbsgc]]
-[[Category: Transferase]]