1kjt: Difference between revisions

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-[[Image:1kjt.gif|left|200px]]<br /><applet load="1kjt" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1kjt, resolution 2.0&Aring;" />
-'''Crystal Structure of the GABA(A) Receptor Associated Protein, GABARAP'''<br />
-==Overview==
+==Crystal Structure of the GABA(A) Receptor Associated Protein, GABARAP==
-The GABA(A)-receptor-associated protein (GABARAP) is a member of a growing family of intracellular membrane trafficking and/or fusion proteins and has been implicated in plasma membrane targeting and/or recycling of GABA(A) receptors. GABARAP is localized on intracellular membranes such as the trans-Golgi network, binds to the gamma 2 subunit of GABA(A) receptors and interacts with microtubules and the N-ethylmaleimide-sensitive factor. We report the X-ray crystal structure of mammalian GABARAP at 2.0 A resolution. GABARAP consists of an N-terminal basic helical region, which has been implicated in tubulin binding, and a core structure with a conserved ubiquitin-like fold. Consistent with the high extent of sequence conservation among GABARAP homologues from plants to mammals, one face of the core structure is absolutely conserved while the opposite face shows considerable divergence. These features are in agreement with the conserved surface mediating protein-protein interactions shared by all members of the family, whereas the non-conserved surface region may play specific roles, such as docking to particular membrane receptors.
+<StructureSection load='1kjt' size='340' side='right'caption='[[1kjt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1kjt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJT FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kjt OCA], [https://pdbe.org/1kjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kjt RCSB], [https://www.ebi.ac.uk/pdbsum/1kjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kjt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GBRAP_RAT GBRAP_RAT] Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity).<ref>PMID:11461150</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kjt_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kjt ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-KJT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NI:'>NI</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJT OCA].
+*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
+== References ==
-==Reference==
+<references/>
-Crystal structure of the GABA(A)-receptor-associated protein, GABARAP., Bavro VN, Sola M, Bracher A, Kneussel M, Betz H, Weissenhorn W, EMBO Rep. 2002 Feb;3(2):183-9. Epub 2002 Jan 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11818336 11818336]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Single protein]]
+[[Category: Bavro VN]]
-[[Category: Bavro, V N.]]
+[[Category: Betz H]]
-[[Category: Betz, H.]]
+[[Category: Bracher A]]
-[[Category: Bracher, A.]]
+[[Category: Kneussel M]]
-[[Category: Kneussel, M.]]
+[[Category: Sola M]]
-[[Category: Sola, M.]]
+[[Category: Weissenhorn W]]
-[[Category: Weissenhorn, W.]]
-[[Category: NA]]
-[[Category: NI]]
-[[Category: n-terminal alpha helical region]]
-[[Category: ubiquitin-like fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:34:52 2008''