1kit: Difference between revisions

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[[Image:1kit.png|left|200px]]


{{STRUCTURE_1kit|  PDB=1kit  |  SCENE= }}
==VIBRIO CHOLERAE NEURAMINIDASE==
 
<StructureSection load='1kit' size='340' side='right'caption='[[1kit]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===VIBRIO CHOLERAE NEURAMINIDASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KIT FirstGlance]. <br>
{{ABSTRACT_PUBMED_7922030}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kit OCA], [https://pdbe.org/1kit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kit RCSB], [https://www.ebi.ac.uk/pdbsum/1kit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kit ProSAT]</span></td></tr>
[[1kit]] is a 1 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANH_VIBCH NANH_VIBCH] Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. Facilitates cholera toxin binding to host intestinal epithelial cells by converting cell surface polysialogangliosides to GM1 monogangliosides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1kit_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kit ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Neuraminidase|Neuraminidase]]
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:007922030</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Exo-alpha-sialidase]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
[[Category: Crennell, S J.]]
[[Category: Crennell SJ]]
[[Category: Garman, E F.]]
[[Category: Garman EF]]
[[Category: Laver, W G.]]
[[Category: Laver WG]]
[[Category: Taylor, G L.]]
[[Category: Taylor GL]]
[[Category: Vimr, E R.]]
[[Category: Vimr ER]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]

Latest revision as of 10:25, 14 February 2024

VIBRIO CHOLERAE NEURAMINIDASEVIBRIO CHOLERAE NEURAMINIDASE

Structural highlights

1kit is a 1 chain structure with sequence from Vibrio cholerae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NANH_VIBCH Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. Facilitates cholera toxin binding to host intestinal epithelial cells by converting cell surface polysialogangliosides to GM1 monogangliosides.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1kit, resolution 2.30Å

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