1ki4: Difference between revisions

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-{{Seed}}
-[[Image:1ki4.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE==
-The line below this paragraph, containing "STRUCTURE_1ki4", creates the "Structure Box" on the page.
+<StructureSection load='1ki4' size='340' side='right'caption='[[1ki4]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ki4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTD:5-BROMOTHIENYLDEOXYURIDINE'>BTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1ki4|  PDB=1ki4  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki4 OCA], [https://pdbe.org/1ki4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki4 ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE===
+==See Also==
+*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_9715911}}, adds the Publication Abstract to the page
+[[Category: Human alphaherpesvirus 1 strain 17]]
-(as it appears on PubMed at http://www.pubmed.gov), where 9715911 is the PubMed ID number.
+[[Category: Large Structures]]
--->
+[[Category: Bennett MS]]
-{{ABSTRACT_PUBMED_9715911}}
+[[Category: Champness JN]]
+[[Category: Sanderson MR]]
-==About this Structure==
+[[Category: Summers WC]]
-KI4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI4 OCA].
+[[Category: Visse R]]
+[[Category: Wien F]]
-==Reference==
-<ref group="xtra">PMID:9715911</ref><references group="xtra"/>
-[[Category: Human herpesvirus 1]]
-[[Category: Thymidine kinase]]
-[[Category: Bennett, M S.]]
-[[Category: Champness, J N.]]
-[[Category: Sanderson, M R.]]
-[[Category: Summers, W C.]]
-[[Category: Visse, R.]]
-[[Category: Wien, F.]]
-[[Category: 5-bromothienyldeoxyuridine]]
-[[Category: Alphaherpesvirinae]]
-[[Category: Ds-dna enveloped viruse]]
-[[Category: Herpesviridae]]
-[[Category: Phosphotransferase]]
-[[Category: Substrate analog]]
-[[Category: Thymidine kinase]]
-[[Category: Viridae]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:01:12 2009''