1ki2: Difference between revisions

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[[Image:1ki2.png|left|200px]]


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==CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR==
The line below this paragraph, containing "STRUCTURE_1ki2", creates the "Structure Box" on the page.
<StructureSection load='1ki2' size='340' side='right'caption='[[1ki2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ki2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GA2:9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE'>GA2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1ki2| PDB=1ki2 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki2 OCA], [https://pdbe.org/1ki2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki2 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR===
==See Also==
 
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_9715911}}, adds the Publication Abstract to the page
[[Category: Human alphaherpesvirus 1 strain 17]]
(as it appears on PubMed at http://www.pubmed.gov), where 9715911 is the PubMed ID number.
[[Category: Large Structures]]
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[[Category: Bennett MS]]
{{ABSTRACT_PUBMED_9715911}}
[[Category: Brown DG]]
 
[[Category: Champness JN]]
==About this Structure==
[[Category: Davies A]]
1KI2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI2 OCA].
[[Category: Melitz C]]
 
[[Category: Rizkallah PJ]]
==Reference==
[[Category: Sanderson MR]]
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands., Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR, Proteins. 1998 Aug 15;32(3):350-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9715911 9715911]
[[Category: Sandhu G]]
[[Category: Human herpesvirus 1]]
[[Category: Summers WC]]
[[Category: Single protein]]
[[Category: Visse R]]
[[Category: Thymidine kinase]]
[[Category: Wien F]]
[[Category: Bennett, M S.]]
[[Category: Brown, D G.]]
[[Category: Champness, J N.]]
[[Category: Davies, A.]]
[[Category: Melitz, C.]]
[[Category: Rizkallah, P J.]]
[[Category: Sanderson, M R.]]
[[Category: Sandhu, G.]]
[[Category: Summers, W C.]]
[[Category: Visse, R.]]
[[Category: Wien, F.]]
[[Category: Alphaherpesvirinae]]
[[Category: Antiviral drug]]
[[Category: Ds-dna enveloped viruse]]
[[Category: Ganciclovir]]
[[Category: Herpesviridae]]
[[Category: Phosphotransferase]]
[[Category: Thymidine kinase]]
[[Category: Viridae]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 10:22:43 2008''

Latest revision as of 10:25, 14 February 2024

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIRCRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR

Structural highlights

1ki2 is a 2 chain structure with sequence from Human alphaherpesvirus 1 strain 17. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KITH_HHV11 In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ki2, resolution 2.20Å

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