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[[Image:1ki2.png|left|200px]]


{{STRUCTURE_1ki2|  PDB=1ki2  |  SCENE=  }}
==CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR==
 
<StructureSection load='1ki2' size='340' side='right'caption='[[1ki2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ki2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI2 FirstGlance]. <br>
{{ABSTRACT_PUBMED_9715911}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GA2:9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE'>GA2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki2 OCA], [https://pdbe.org/1ki2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki2 ProSAT]</span></td></tr>
[[1ki2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI2 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki2 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thymidine kinase|Thymidine kinase]]
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009715911</ref><references group="xtra"/>
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Thymidine kinase]]
[[Category: Large Structures]]
[[Category: Viruses]]
[[Category: Bennett MS]]
[[Category: Bennett, M S.]]
[[Category: Brown DG]]
[[Category: Brown, D G.]]
[[Category: Champness JN]]
[[Category: Champness, J N.]]
[[Category: Davies A]]
[[Category: Davies, A.]]
[[Category: Melitz C]]
[[Category: Melitz, C.]]
[[Category: Rizkallah PJ]]
[[Category: Rizkallah, P J.]]
[[Category: Sanderson MR]]
[[Category: Sanderson, M R.]]
[[Category: Sandhu G]]
[[Category: Sandhu, G.]]
[[Category: Summers WC]]
[[Category: Summers, W C.]]
[[Category: Visse R]]
[[Category: Visse, R.]]
[[Category: Wien F]]
[[Category: Wien, F.]]
[[Category: Alphaherpesvirinae]]
[[Category: Antiviral drug]]
[[Category: Ds-dna enveloped viruse]]
[[Category: Ganciclovir]]
[[Category: Herpesviridae]]
[[Category: Phosphotransferase]]
[[Category: Thymidine kinase]]
[[Category: Viridae]]

Latest revision as of 10:25, 14 February 2024

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIRCRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR

Structural highlights

1ki2 is a 2 chain structure with sequence from Human alphaherpesvirus 1 strain 17. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KITH_HHV11 In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ki2, resolution 2.20Å

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OCA
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