1ki1: Difference between revisions

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-[[Image:1ki1.png|left|200px]]
-<!--
+==Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42==
-The line below this paragraph, containing "STRUCTURE_1ki1", creates the "Structure Box" on the page.
+<StructureSection load='1ki1' size='340' side='right'caption='[[1ki1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ki1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1ki1|  PDB=1ki1  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki1 OCA], [https://pdbe.org/1ki1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki1 ConSurf].
+<div style="clear:both"></div>
-===Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42===
+==See Also==
+*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
+*[[Intersectin|Intersectin]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_12006984}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 12006984 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_12006984}}
-==About this Structure==
-[[1ki1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI1 OCA].
-==Reference==
-<ref group="xtra">PMID:012006984</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Der, C J.]]
+[[Category: Large Structures]]
-[[Category: Pruitt, W M.]]
+[[Category: Der CJ]]
-[[Category: Snyder, J T.]]
+[[Category: Pruitt WM]]
-[[Category: Sondek, J.]]
+[[Category: Snyder JT]]
-[[Category: Dh domain]]
+[[Category: Sondek J]]
-[[Category: Ph domain]]
-[[Category: Protein-protein complex]]
-[[Category: Rho gtpase]]
-[[Category: Signaling protein]]