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==Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.==
==Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.==
<StructureSection load='1kh6' size='340' side='right' caption='[[1kh6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='1kh6' size='340' side='right'caption='[[1kh6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kh6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KH6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kh6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KH6 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kh6 OCA], [http://pdbe.org/1kh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kh6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kh6 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kh6 OCA], [https://pdbe.org/1kh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kh6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kh6 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA drives internal initiation of viral protein synthesis during host cell infection. In the tertiary structure of the IRES RNA, two helical junctions create recognition sites for direct binding of the 40S ribosomal subunit and eukaryotic initiation factor 3 (eIF3). The 2.8 A resolution structure of the IIIabc four-way junction, which is critical for binding eIF3, reveals how junction nucleotides interact with an adjacent helix to position regions directly involved in eIF3 recognition. Two of the emergent helices stack to form a nearly continuous A-form duplex, while stacking of the other two helices is interrupted by the insertion of junction residues into the helix minor groove. This distorted stack probably serves as an important recognition surface for the translational machinery.
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation.,Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA Nat Struct Biol. 2002 May;9(5):370-4. PMID:11927953<ref>PMID:11927953</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1kh6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Doudna, J A]]
[[Category: Large Structures]]
[[Category: Grech, A]]
[[Category: Doudna JA]]
[[Category: Jubin, R]]
[[Category: Grech A]]
[[Category: Kieft, J S]]
[[Category: Jubin R]]
[[Category: Zhou, K]]
[[Category: Kieft JS]]
[[Category: Bromine]]
[[Category: Zhou K]]
[[Category: Four-way junction]]
[[Category: Hcv]]
[[Category: Ire]]
[[Category: Rna]]
[[Category: Rna structure]]
[[Category: Translation]]

Latest revision as of 10:24, 14 February 2024

Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.

Structural highlights

1kh6 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1kh6, resolution 2.90Å

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OCA
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