1cg2: Difference between revisions

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-{{Seed}}
-[[Image:1cg2.png|left|200px]]
-<!--
+==CARBOXYPEPTIDASE G2==
-The line below this paragraph, containing "STRUCTURE_1cg2", creates the "Structure Box" on the page.
+<StructureSection load='1cg2' size='340' side='right'caption='[[1cg2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1cg2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._RS-16 Pseudomonas sp. RS-16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CG2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1cg2|  PDB=1cg2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cg2 OCA], [https://pdbe.org/1cg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cg2 RCSB], [https://www.ebi.ac.uk/pdbsum/1cg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cg2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CBPG_PSES6 CBPG_PSES6] Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/1cg2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cg2 ConSurf].
+<div style="clear:both"></div>
-===CARBOXYPEPTIDASE G2===
+==See Also==
+*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_9083113}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 9083113 is the PubMed ID number.
+[[Category: Pseudomonas sp. RS-16]]
--->
+[[Category: Blow DM]]
-{{ABSTRACT_PUBMED_9083113}}
+[[Category: Brick P]]
+[[Category: Melton RG]]
-==About this Structure==
+[[Category: Pauptit RA]]
-CG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CG2 OCA].
+[[Category: Rowsell S]]
+[[Category: Tucker AD]]
-==Reference==
-Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy., Rowsell S, Pauptit RA, Tucker AD, Melton RG, Blow DM, Brick P, Structure. 1997 Mar 15;5(3):337-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9083113 9083113]
-[[Category: Glutamate carboxypeptidase]]
-[[Category: Pseudomonas sp.]]
-[[Category: Single protein]]
-[[Category: Blow, D M.]]
-[[Category: Brick, P.]]
-[[Category: Melton, R G.]]
-[[Category: Pauptit, R A.]]
-[[Category: Rowsell, S.]]
-[[Category: Tucker, A D.]]
-[[Category: Hydrolase]]
-[[Category: Metallocarboxypeptidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:42:09 2008''