8wo3: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8wo3 is ON HOLD
+==Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Mupirocin==
+<StructureSection load='8wo3' size='340' side='right'caption='[[8wo3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Guo, Y., Li, S., Zhang, T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8wo3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WO3 FirstGlance]. <br>
-Description: Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Mupirocin
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRC:MUPIROCIN'>MRC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Li, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wo3 OCA], [https://pdbe.org/8wo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wo3 RCSB], [https://www.ebi.ac.uk/pdbsum/8wo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wo3 ProSAT]</span></td></tr>
-[[Category: Zhang, T]]
+</table>
-[[Category: Guo, Y]]
+== Function ==
+[https://www.uniprot.org/uniprot/A0A2J9KLI1_HELPX A0A2J9KLI1_HELPX] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).[ARBA:ARBA00025217][HAMAP-Rule:MF_02002]
+__TOC__
+</StructureSection>
+[[Category: Helicobacter pylori]]
+[[Category: Large Structures]]
+[[Category: Guo Y]]
+[[Category: Li S]]
+[[Category: Zhang T]]