8v1l: Difference between revisions

Latest revision as of 10:22, 14 February 2024

Crystal structure of the NTF2L domain of human G3BP1 in complex with small moleculeCrystal structure of the NTF2L domain of human G3BP1 in complex with small molecule

Structural highlights

8v1l is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.68Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G3BP1_HUMAN May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.^[1] ^[2]

References

↑ Costa M, Ochem A, Staub A, Falaschi A. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. PMID:9889278
↑ Tourriere H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, Tazi J. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. PMID:11604510 doi:10.1128/MCB.21.22.7747-7760.2001

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OCA

[1] Costa M, Ochem A, Staub A, Falaschi A. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. PMID:9889278

[2] Tourriere H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, Tazi J. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. PMID:11604510 doi:10.1128/MCB.21.22.7747-7760.2001

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8v1l is ON HOLD
+==Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule==
+<StructureSection load='8v1l' size='340' side='right'caption='[[8v1l]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
-Authors: Hughes, M.P., Taylor, J.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8v1l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V1L FirstGlance]. <br>
-Description: Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y9M:N-[(2S)-2-fluoro-4,4-dimethylpentanoyl]-3-hydroxy-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-D-alanyl-N-benzyl-N,O-dimethyl-L-homoserinamide'>Y9M</scene></td></tr>
-[[Category: Hughes, M.P]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v1l OCA], [https://pdbe.org/8v1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v1l RCSB], [https://www.ebi.ac.uk/pdbsum/8v1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v1l ProSAT]</span></td></tr>
-[[Category: Taylor, J.P]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hughes MP]]
+[[Category: Taylor JP]]

8v1l: Difference between revisions

Latest revision as of 10:22, 14 February 2024

Crystal structure of the NTF2L domain of human G3BP1 in complex with small moleculeCrystal structure of the NTF2L domain of human G3BP1 in complex with small molecule

Structural highlights

Function

References

Contents

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8v1l: Difference between revisions

Latest revision as of 10:22, 14 February 2024

Crystal structure of the NTF2L domain of human G3BP1 in complex with small moleculeCrystal structure of the NTF2L domain of human G3BP1 in complex with small molecule

Structural highlights

Function

References

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