5ql9: Difference between revisions

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'''Unreleased structure'''


The entry 5ql9 is ON HOLD
==Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure B9_2)==
 
<StructureSection load='5ql9' size='340' side='right'caption='[[5ql9]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
Authors: Ilyichova, O.V., Bentley, M.R., Doak, B.C., Scanlon, M.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ql9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QL9 FirstGlance]. <br>
Description: Group deposition of library data -Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure B9_2)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.151&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ql9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ql9 OCA], [https://pdbe.org/5ql9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ql9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ql9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ql9 ProSAT]</span></td></tr>
[[Category: Doak, B.C]]
</table>
[[Category: Ilyichova, O.V]]
== Function ==
[[Category: Scanlon, M.J]]
[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>
[[Category: Bentley, M.R]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Bentley MR]]
[[Category: Doak BC]]
[[Category: Ilyichova OV]]
[[Category: Scanlon MJ]]

Latest revision as of 11:58, 7 February 2024

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure B9_2)Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure B9_2)

Structural highlights

5ql9 is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.151Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DSBA_ECOLI Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.[1] [2]

References

  1. ↑ Akiyama Y, Kamitani S, Kusukawa N, Ito K. In vitro catalysis of oxidative folding of disulfide-bonded proteins by the Escherichia coli dsbA (ppfA) gene product. J Biol Chem. 1992 Nov 5;267(31):22440-5. PMID:1429594
  2. ↑ Lippa AM, Goulian M. Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli. J Bacteriol. 2012 Mar;194(6):1457-63. doi: 10.1128/JB.06055-11. Epub 2012 Jan 20. PMID:22267510 doi:http://dx.doi.org/10.1128/JB.06055-11

5ql9, resolution 2.15Å

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