5qef: Difference between revisions

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==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134a==
==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134a==
<StructureSection load='5qef' size='340' side='right' caption='[[5qef]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5qef' size='340' side='right'caption='[[5qef]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5qef]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QEF FirstGlance]. <br>
<table><tr><td colspan='2'>[[5qef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QEF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JJ7:1-{4-[(2-methoxyethyl)amino]piperidin-1-yl}ethan-1-one'>JJ7</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.605&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJ7:1-{4-[(2-methoxyethyl)amino]piperidin-1-yl}ethan-1-one'>JJ7</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qef OCA], [http://pdbe.org/5qef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qef RCSB], [http://www.ebi.ac.uk/pdbsum/5qef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qef ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qef OCA], [https://pdbe.org/5qef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qef RCSB], [https://www.ebi.ac.uk/pdbsum/5qef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qef ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>  
 
==See Also==
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Homo sapiens]]
[[Category: Biel, J T]]
[[Category: Large Structures]]
[[Category: Brandao-Neto, J]]
[[Category: Biel JT]]
[[Category: Delft, F von]]
[[Category: Brandao-Neto J]]
[[Category: Fraser, J S]]
[[Category: Fraser JS]]
[[Category: Hill, Z B]]
[[Category: Hill ZB]]
[[Category: Kang, E]]
[[Category: Kang E]]
[[Category: Keedy, D A]]
[[Category: Keedy DA]]
[[Category: Rettenmaier, T J]]
[[Category: Rettenmaier TJ]]
[[Category: Wells, J A]]
[[Category: Wells JA]]
[[Category: Allostery]]
[[Category: Von Delft F]]
[[Category: Enzyme]]
[[Category: Hydrolase]]
[[Category: Multiconformer]]
[[Category: Pandda]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Ptp]]
[[Category: Ptp1b]]
[[Category: Sgc - diamond i04-1 fragment screening]]

Latest revision as of 11:52, 7 February 2024

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134aPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134a

Structural highlights

5qef is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.605Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTN1_HUMAN Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2]

See Also

References

  1. ↑ Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010, Dec 6. PMID:21135139 doi:10.1083/jcb.201005035
  2. ↑ Krishnan N, Fu C, Pappin DJ, Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. PMID:22169477 doi:10.1126/scisignal.2002329

5qef, resolution 1.60Å

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