3jv4: Difference between revisions

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-{{Seed}}
-[[Image:3jv4.jpg|left|200px]]
-<!--
+==Crystal structure of the dimerization domains p50 and RelB==
-The line below this paragraph, containing "STRUCTURE_3jv4", creates the "Structure Box" on the page.
+<StructureSection load='3jv4' size='340' side='right'caption='[[3jv4]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3jv4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JV4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jv4 OCA], [https://pdbe.org/3jv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jv4 RCSB], [https://www.ebi.ac.uk/pdbsum/3jv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jv4 ProSAT]</span></td></tr>
-{{STRUCTURE_3jv4|  PDB=3jv4  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
-===Crystal structure of the dimerization domains p50 and RelB===
+==See Also==
+*[[NF-kB|NF-kB]]
+== References ==
-==About this Structure==
+<references/>
-JV4 is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV4 OCA].
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Ghosh, G.]]
+[[Category: Ghosh G]]
-[[Category: Huang, D B.]]
+[[Category: Huang DB]]
-[[Category: Vu, D.]]
+[[Category: Vu D]]
-[[Category: Activator]]
-[[Category: Ank repeat]]
-[[Category: Apoptosis]]
-[[Category: Dna-binding]]
-[[Category: Heterodimer]]
-[[Category: Nf-kb protein]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Relb and p50]]
-[[Category: S-nitrosylation]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:13:07 2010''