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New page: '''Unreleased structure''' The entry 3jav is ON HOLD Authors: Fan G, Baker ML, Wang Z, Baker MR, Sinyagovsky PA, Chiu W, Ludtke SJ, Serysheva II Description: Structure of IP3R1 at near... |
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==Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM== | |||
<SX load='3jav' size='340' side='right' viewer='molstar' caption='[[3jav]], [[Resolution|resolution]] 4.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3jav]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.7Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jav OCA], [https://pdbe.org/3jav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jav RCSB], [https://www.ebi.ac.uk/pdbsum/3jav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jav ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | |||
==See Also== | |||
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | |||
__TOC__ | |||
[[Category: | </SX> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Baker ML]] | |||
[[Category: Baker MR]] | |||
[[Category: Chiu W]] | |||
[[Category: Fan G]] | |||
[[Category: Ludtke SJ]] | |||
[[Category: Serysheva II]] | |||
[[Category: Sinyagovskiy PA]] | |||
[[Category: Wang Z]] | |||
Latest revision as of 11:42, 7 February 2024
Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EMStructure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM
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