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==Atomic structures of a bactericidal contractile nanotube in its pre- and post-contraction states==
==Atomic structures of a bactericidal contractile nanotube in its pre- and post-contraction states==
<StructureSection load='3j9q' size='340' side='right' caption='[[3j9q]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='3j9q' size='340' side='right' viewer='molstar' caption='[[3j9q]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3j9q]] is a 48 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J9Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[3j9q]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J9Q FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j9r|3j9r]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j9q RCSB], [http://www.ebi.ac.uk/pdbsum/3j9q PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9q OCA], [https://pdbe.org/3j9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j9q RCSB], [https://www.ebi.ac.uk/pdbsum/3j9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9q ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q9S574_PSEAI Q9S574_PSEAI]
R-type pyocins are representatives of contractile ejection systems, a class of biological nanomachines that includes, among others, the bacterial type VI secretion system (T6SS) and contractile bacteriophage tails. We report atomic models of the Pseudomonas aeruginosa precontraction pyocin sheath and tube, and the postcontraction sheath, obtained by cryo-EM at 3.5-A and 3.9-A resolutions, respectively. The central channel of the tube is negatively charged, in contrast to the neutral and positive counterparts in T6SSs and phage tails. The sheath is interwoven by long N- and C-terminal extension arms emanating from each subunit, which create an extensive two-dimensional mesh that has the same connectivity in the extended and contracted state of the sheath. We propose that the contraction process draws energy from electrostatic and shape complementarities to insert the inner tube through bacterial cell membranes to eventually kill the bacteria.
 
Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states.,Ge P, Scholl D, Leiman PG, Yu X, Miller JF, Zhou ZH Nat Struct Mol Biol. 2015 Mar 30. doi: 10.1038/nsmb.2995. PMID:25822993<ref>PMID:25822993</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Ge, P]]
[[Category: Ge P]]
[[Category: Leiman, P G]]
[[Category: Leiman PG]]
[[Category: Miller, J F]]
[[Category: Miller JF]]
[[Category: Scholl, D]]
[[Category: Scholl D]]
[[Category: Yu, X]]
[[Category: Yu X]]
[[Category: Zhou, Z H]]
[[Category: Zhou ZH]]
[[Category: Bacteriocin]]
[[Category: Pyocin]]
[[Category: Sheath]]
[[Category: Structural protein]]
[[Category: Tube]]

Latest revision as of 11:41, 7 February 2024

Atomic structures of a bactericidal contractile nanotube in its pre- and post-contraction statesAtomic structures of a bactericidal contractile nanotube in its pre- and post-contraction states

3j9q, resolution 3.50Å

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