8bv4: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8bv4 is ON HOLD
+==Structure of BlaC from Mycobacterium tuberculosis in complex with vaborbactam==
+<StructureSection load='8bv4' size='340' side='right'caption='[[8bv4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-Authors: Chikunova, A., Bruenle, S., Ubbink, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8bv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BV4 FirstGlance]. <br>
-Description: Structure of BlaC from Mycobacterium tuberculosis in complex with vaborbactam
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4D6:{(3R,6S)-2-HYDROXY-3-[(THIOPHEN-2-YLACETYL)AMINO]-1,2-OXABORINAN-6-YL}ACETIC+ACID'>4D6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Ubbink, M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bv4 OCA], [https://pdbe.org/8bv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bv4 RCSB], [https://www.ebi.ac.uk/pdbsum/8bv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bv4 ProSAT]</span></td></tr>
-[[Category: Chikunova, A]]
+</table>
-[[Category: Bruenle, S]]
+== Function ==
+[https://www.uniprot.org/uniprot/BLAC_MYCTA BLAC_MYCTA] Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Exhibits predominant penicillinase activity. Also displays high levels of cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of M.tuberculosis to beta-lactam antibiotics.[UniProtKB:P9WKD3]<ref>PMID:9624479</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Bruenle S]]
+[[Category: Chikunova A]]
+[[Category: Ubbink M]]