7zi9: Difference between revisions

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'''Unreleased structure'''


The entry 7zi9 is ON HOLD  until 2024-04-07
==Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0624 inhibitor==
 
<StructureSection load='7zi9' size='340' side='right'caption='[[7zi9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Saez-Ayala, M., Ben-Yaala, K., Betzi, S., Rebuffet, E., Morelli, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7zi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZI9 FirstGlance]. <br>
Description: Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0624 inhibitor
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J6M:2-[2-[[2-methyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]phenyl]-propyl-amino]-1,3-thiazol-4-yl]pyrimidine-4,6-diamine'>J6M</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
[[Category: Rebuffet, E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zi9 OCA], [https://pdbe.org/7zi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zi9 RCSB], [https://www.ebi.ac.uk/pdbsum/7zi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zi9 ProSAT]</span></td></tr>
[[Category: Ben-Yaala, K]]
</table>
[[Category: Morelli, X]]
== Function ==
[[Category: Betzi, S]]
[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
[[Category: Saez-Ayala, M]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ben-Yaala K]]
[[Category: Betzi S]]
[[Category: Morelli X]]
[[Category: Rebuffet E]]
[[Category: Saez-Ayala M]]

Latest revision as of 11:03, 7 February 2024

Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0624 inhibitorCrystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0624 inhibitor

Structural highlights

7zi9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCK_HUMAN Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.[1] [2]

References

  1. ↑ Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Structural basis for substrate promiscuity of dCK. J Mol Biol. 2008 May 2;378(3):607-21. Epub 2008 Mar 3. PMID:18377927 doi:http://dx.doi.org/10.1016/j.jmb.2008.02.061
  2. ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e

7zi9, resolution 1.80Å

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