7qpm: Difference between revisions
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New page: '''Unreleased structure''' The entry 7qpm is ON HOLD until Paper Publication Authors: Leonard, P.M., Langgard, M. Description: Discovery of Lu AF11167, a Phosphodiesterase 10A inhibito... |
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==Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate== | |||
<StructureSection load='7qpm' size='340' side='right'caption='[[7qpm]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7qpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QPM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EEI:5,7-dimethyl-2-[(1-methyl-4-phenyl-imidazol-2-yl)sulfanylmethyl]imidazo[1,2-a]pyrimidine'>EEI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qpm OCA], [https://pdbe.org/7qpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qpm RCSB], [https://www.ebi.ac.uk/pdbsum/7qpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qpm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Langgard | __TOC__ | ||
[[Category: Leonard | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Langgard M]] | |||
[[Category: Leonard PM]] | |||
Latest revision as of 10:58, 7 February 2024
Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidateDiscovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
Structural highlights
FunctionPDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1] See AlsoReferences |
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