7azc: Difference between revisions
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New page: '''Unreleased structure''' The entry 7azc is ON HOLD Authors: Monsarrat, C., Compain, G., Andre, C., Martiel, I., Engilberge, S., Olieric, V., Wolff, P., Brillet, K., Landolfo, M., Silv... |
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The | ==DNA polymerase sliding clamp from Escherichia coli with peptide 22 bound== | ||
<StructureSection load='7azc' size='340' side='right'caption='[[7azc]], [[Resolution|resolution]] 1.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7azc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_2-427-07_S4_C3 Escherichia coli 2-427-07_S4_C3] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AZC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=CML:(2S)-2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}BUTANEDIOIC+ACID'>CML</scene>, <scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QU8:~{N}-(4-methoxyphenyl)methanamide'>QU8</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7azc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7azc OCA], [https://pdbe.org/7azc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7azc RCSB], [https://www.ebi.ac.uk/pdbsum/7azc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7azc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. | |||
==See Also== | |||
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Andre | [[Category: Escherichia coli 2-427-07_S4_C3]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Andre C]] | ||
[[Category: | [[Category: Brillet K]] | ||
[[Category: | [[Category: Burnouf DY]] | ||
[[Category: | [[Category: Compain G]] | ||
[[Category: | [[Category: Engilberge S]] | ||
[[Category: | [[Category: Guichard G]] | ||
[[Category: | [[Category: Landolfo M]] | ||
[[Category: | [[Category: Martiel I]] | ||
[[Category: | [[Category: Monsarrat C]] | ||
[[Category: | [[Category: Olieric V]] | ||
[[Category: Silva da Veiga C]] | |||
[[Category: Wagner J]] | |||
[[Category: Wolff P]] | |||
Latest revision as of 10:51, 7 February 2024
DNA polymerase sliding clamp from Escherichia coli with peptide 22 boundDNA polymerase sliding clamp from Escherichia coli with peptide 22 bound
Structural highlights
FunctionDPO3B_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. See Also |
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