6g6j: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6g6j is ON HOLD  until Paper Publication
+==The crystal structures of Human MYC:MAX bHLHZip complex==
+<StructureSection load='6g6j' size='340' side='right'caption='[[6g6j]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6g6j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G6J FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6j OCA], [https://pdbe.org/6g6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g6j RCSB], [https://www.ebi.ac.uk/pdbsum/6g6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6j ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/MYC_HUMAN MYC_HUMAN] Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.  Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.  Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:[https://omim.org/entry/113970 113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
+== Function ==
+[https://www.uniprot.org/uniprot/MYC_HUMAN MYC_HUMAN] Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
-Authors: Allen, M.D., Zinzalla, G.
+==See Also==
+*[[C-Myc|C-Myc]]
-Description: The crystal structures of Human MYC:MAX bHLHZip complex
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Allen, M.D]]
+[[Category: Homo sapiens]]
-[[Category: Zinzalla, G]]
+[[Category: Large Structures]]
+[[Category: Allen MD]]
+[[Category: Zinzalla G]]