5mpv: Difference between revisions

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'''Unreleased structure'''


The entry 5mpv is ON HOLD
==Crystal structure of a Mycobacterium tuberculosis chorismate mutase optimized for high autonomous activity by directed evolution==
<StructureSection load='5mpv' size='340' side='right'caption='[[5mpv]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mpv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MPV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mpv OCA], [https://pdbe.org/5mpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mpv RCSB], [https://www.ebi.ac.uk/pdbsum/5mpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mpv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHMU_MYCTU CHMU_MYCTU] Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.<ref>PMID:15737998</ref> <ref>PMID:18727669</ref> <ref>PMID:19556970</ref>


Authors:  
==See Also==
 
*[[3D structures of chorismate mutase|3D structures of chorismate mutase]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Kamarauskaite J]]
[[Category: Kast P]]
[[Category: Krengel U]]
[[Category: Thorbjornsrud HV]]

Latest revision as of 10:48, 7 February 2024

Crystal structure of a Mycobacterium tuberculosis chorismate mutase optimized for high autonomous activity by directed evolutionCrystal structure of a Mycobacterium tuberculosis chorismate mutase optimized for high autonomous activity by directed evolution

Structural highlights

5mpv is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.49Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHMU_MYCTU Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.[1] [2] [3]

See Also

References

  1. ↑ Prakash P, Aruna B, Sardesai AA, Hasnain SE. Purified recombinant hypothetical protein coded by open reading frame Rv1885c of Mycobacterium tuberculosis exhibits a monofunctional AroQ class of periplasmic chorismate mutase activity. J Biol Chem. 2005 May 20;280(20):19641-8. Epub 2005 Feb 28. PMID:15737998 doi:10.1074/jbc.M413026200
  2. ↑ Kim SK, Reddy SK, Nelson BC, Robinson H, Reddy PT, Ladner JE. A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis. FEBS J. 2008 Oct;275(19):4824-35. Epub 2008 Aug 22. PMID:18727669 doi:10.1111/j.1742-4658.2008.06621.x
  3. ↑ Sasso S, Okvist M, Roderer K, Gamper M, Codoni G, Krengel U, Kast P. Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner. EMBO J. 2009 Jul 22;28(14):2128-42. Epub 2009 Jun 25. PMID:19556970 doi:10.1038/emboj.2009.165

5mpv, resolution 1.49Å

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