2z7x: Difference between revisions

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{{Seed}}
[[Image:2z7x.png|left|200px]]


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==Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide==
The line below this paragraph, containing "STRUCTURE_2z7x", creates the "Structure Box" on the page.
<StructureSection load='2z7x' size='340' side='right'caption='[[2z7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2z7x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z7X FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PCJ:(2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL+DIHEXADECANOATE'>PCJ</scene></td></tr>
{{STRUCTURE_2z7x| PDB=2z7x |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z7x OCA], [https://pdbe.org/2z7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z7x RCSB], [https://www.ebi.ac.uk/pdbsum/2z7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z7x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/2z7x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z7x ConSurf].
<div style="clear:both"></div>


===Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide===
==See Also==
 
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
 
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17889651}}, adds the Publication Abstract to the page
</StructureSection>
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[[Category: Eptatretus burgeri]]
-->
[[Category: Homo sapiens]]
{{ABSTRACT_PUBMED_17889651}}
[[Category: Large Structures]]
 
[[Category: RCSB PDB Molecule of the Month]]
==About this Structure==
[[Category: Synthetic construct]]
2Z7X is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens,_eptatretus_burgeri Homo sapiens, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z7X OCA].
[[Category: Toll-like Receptors]]
 
[[Category: Heo JY]]
==Reference==
[[Category: Jin MS]]
<ref group="xtra">PMID:17889651</ref><references group="xtra"/>
[[Category: Kim SE]]
[[Category: Homo sapiens, eptatretus burgeri]]
[[Category: Lee JO]]
[[Category: Heo, J Y.]]
[[Category: Jin, M S.]]
[[Category: Kim, S E.]]
[[Category: Lee, J O.]]
[[Category: Cytoplasmic vesicle]]
[[Category: Glycoprotein]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Inflammatory response]]
[[Category: Innate immunity]]
[[Category: Leucine-rich repeat]]
[[Category: Lipopeptide]]
[[Category: Membrane]]
[[Category: Pam3csk4]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Tlr1]]
[[Category: Tlr2]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:28:54 2009''

Latest revision as of 10:47, 7 February 2024

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptideCrystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Structural highlights

2z7x is a 3 chain structure with sequence from Eptatretus burgeri, Homo sapiens and Synthetic construct. The November 2011 RCSB PDB Molecule of the Month feature on Toll-like Receptors by David Goodsell is 10.2210/rcsb_pdb/mom_2011_11. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TLR2_HUMAN Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2z7x, resolution 2.10Å

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