2jcp: Difference between revisions

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-[[Image:2jcp.gif|left|200px]]
-<!--
+==The hyaluronan binding domain of murine CD44==
-The line below this paragraph, containing "STRUCTURE_2jcp", creates the "Structure Box" on the page.
+<StructureSection load='2jcp' size='340' side='right'caption='[[2jcp]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2jcp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcp OCA], [https://pdbe.org/2jcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jcp RCSB], [https://www.ebi.ac.uk/pdbsum/2jcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcp ProSAT]</span></td></tr>
-{{STRUCTURE_2jcp|  PDB=2jcp  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jcp ConSurf].
+<div style="clear:both"></div>
-'''THE HYALURONAN BINDING DOMAIN OF MURINE CD44'''
+==See Also==
+*[[CD44|CD44]]
+__TOC__
-==Overview==
+</StructureSection>
-Regulation of transient interactions between cells and the ubiquitous matrix glycosaminoglycan hyaluronan is crucial to such fundamental processes as embryonic development and leukocyte homing. Cd44, the primary cell surface receptor for hyaluronan, binds ligand via a lectin-like fold termed the Link module, but only after appropriate functional activation. The molecular details of the Cd44-hyaluronan interaction and hence the structural basis for this activation are unknown. Here we present the first crystal structure of Cd44 complexed with hyaluronan. This reveals that the interaction with hyaluronan is dominated by shape and hydrogen-bonding complementarity and identifies two conformational forms of the receptor that differ in orientation of a crucial hyaluronan-binding residue (Arg45, equivalent to Arg41 in human CD44). Measurements by NMR indicate that the conformational transition can be induced by hyaluronan binding, providing further insight into possible mechanisms for regulation of Cd44.
+[[Category: Large Structures]]
-==About this Structure==
-JCP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCP OCA].
-==Reference==
-Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction., Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG, Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17293874 17293874]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Banerji S]]
-[[Category: Banerji, S.]]
+[[Category: Campbell ID]]
-[[Category: Campbell, I D.]]
+[[Category: Day AJ]]
-[[Category: Day, A J.]]
+[[Category: Jackson DG]]
-[[Category: Jackson, D G.]]
+[[Category: Mahoney DJ]]
-[[Category: Mahoney, D J.]]
+[[Category: Noble MEM]]
-[[Category: Noble, M E.M.]]
+[[Category: Wright AJ]]
-[[Category: Wright, A J.]]
-[[Category: Alternative splicing]]
-[[Category: Antigen]]
-[[Category: Blood group antigen]]
-[[Category: C-type lectin]]
-[[Category: Cell adhesion]]
-[[Category: Extracellular matrix]]
-[[Category: Glycoprotein]]
-[[Category: Hyauronan]]
-[[Category: Lectin]]
-[[Category: Link-domain]]
-[[Category: Membrane]]
-[[Category: Phosphorylation]]
-[[Category: Polymorphism]]
-[[Category: Proteoglycan]]
-[[Category: Pyrrolidone carboxylic acid]]
-[[Category: Receptor]]
-[[Category: Sugar- binding]]
-[[Category: Sugar-binding protein]]
-[[Category: Sulfation]]
-[[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  7 08:44:24 2008''