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[[Image:1kcf.png|left|200px]]


{{STRUCTURE_1kcf|  PDB=1kcf  |  SCENE=  }}
==Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2==
 
<StructureSection load='1kcf' size='340' side='right'caption='[[1kcf]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kcf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCF FirstGlance]. <br>
{{ABSTRACT_PUBMED_11726496}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcf OCA], [https://pdbe.org/1kcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcf RCSB], [https://www.ebi.ac.uk/pdbsum/1kcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcf ProSAT]</span></td></tr>
[[1kcf]] is a 2 chain structure of [[Resolvase]] with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCF OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCE1_SCHPO CCE1_SCHPO] Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' and 5'-TT-3' sequences.<ref>PMID:9343409</ref> <ref>PMID:10954073</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kcf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kcf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Resolvase|Resolvase]]
*[[Resolvase|Resolvase]]
 
*[[Resolvase 3D structures|Resolvase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:011726496</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Barrett, T E.]]
[[Category: Barrett TE]]
[[Category: Ceschini, S.]]
[[Category: Ceschini S]]
[[Category: Keeley, A.]]
[[Category: Keeley A]]
[[Category: McAlister, M S.B.]]
[[Category: McAlister MSB]]
[[Category: Oram, M.]]
[[Category: Oram M]]
[[Category: Pearl, L H.]]
[[Category: Pearl LH]]
[[Category: Phelan, J.]]
[[Category: Phelan J]]
[[Category: Tsaneva, I R.]]
[[Category: Tsaneva IR]]
[[Category: Beta-alpha-beta motif]]
[[Category: Hydrolase]]
[[Category: Ruvc resolvase family]]

Latest revision as of 10:45, 7 February 2024

Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2

Structural highlights

1kcf is a 2 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CCE1_SCHPO Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' and 5'-TT-3' sequences.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ White MF, Lilley DM. Characterization of a Holliday junction-resolving enzyme from Schizosaccharomyces pombe. Mol Cell Biol. 1997 Nov;17(11):6465-71. PMID:9343409
  2. ↑ Doe CL, Osman F, Dixon J, Whitby MC. The Holliday junction resolvase SpCCE1 prevents mitochondrial DNA aggregation in Schizosaccharomyces pombe. Mol Gen Genet. 2000 Jul;263(6):889-97. PMID:10954073

1kcf, resolution 2.30Å

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