1k90: Difference between revisions

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-[[Image:1k90.png|left|200px]]
-{{STRUCTURE_1k90|  PDB=1k90  |  SCENE=  }}
+==Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP==
+<StructureSection load='1k90' size='340' side='right'caption='[[1k90]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-===Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1k90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Anthrax Toxin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_4 10.2210/rcsb_pdb/mom_2002_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K90 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11807546}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AT:3-DEOXYADENOSINE-5-TRIPHOSPHATE'>3AT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k90 OCA], [https://pdbe.org/1k90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k90 RCSB], [https://www.ebi.ac.uk/pdbsum/1k90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k90 ProSAT]</span></td></tr>
-[[1k90]] is a 6 chain structure of [[Adenylyl cyclase]] and [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2002 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Anthrax Toxin''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2002_4 10.2210/rcsb_pdb/mom_2002_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K90 OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.  The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
+== Function ==
+[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k90_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k90 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Adenylyl cyclase|Adenylyl cyclase]]
+*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]]
-*[[Calmodulin|Calmodulin]]
+*[[Calmodulin 3D structures|Calmodulin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:011807546</ref><references group="xtra"/>
+__TOC__
-[[Category: Adenylate cyclase]]
+</StructureSection>
 [[Category: Anthrax Toxin]]
 [[Category: Bacillus anthracis]]
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: RCSB PDB Molecule of the Month]]
-[[Category: Bard, J.]]
+[[Category: Bard J]]
-[[Category: Bohm, A.]]
+[[Category: Bohm A]]
-[[Category: Drum, C L.]]
+[[Category: Drum CL]]
-[[Category: Grabarek, Z.]]
+[[Category: Grabarek Z]]
-[[Category: Lu, D.]]
+[[Category: Lu D]]
-[[Category: Shen, Y Q.]]
+[[Category: Shen Y-Q]]
-[[Category: Soelaiman, S.]]
+[[Category: Soelaiman S]]
-[[Category: Tang, W J.]]
+[[Category: Tang W-J]]
-[[Category: Yan, S Z.]]
+[[Category: Yan S-Z]]
-[[Category: Lyase-metal binding protein complex]]
-[[Category: Oedema factor adenylyl cyclase anthrax calmodulin]]
-[[Category: Toxin]]