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< | ==Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)== | ||
<StructureSection load='1k8t' size='340' side='right'caption='[[1k8t]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1k8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. The April 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Anthrax Toxin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_4 10.2210/rcsb_pdb/mom_2002_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
--> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8t OCA], [https://pdbe.org/1k8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8t RCSB], [https://www.ebi.ac.uk/pdbsum/1k8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host. | |||
=== | ==See Also== | ||
*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Anthrax Toxin]] | [[Category: Anthrax Toxin]] | ||
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bard | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Bohm | [[Category: Bard J]] | ||
[[Category: Drum | [[Category: Bohm A]] | ||
[[Category: Grabarek | [[Category: Drum CL]] | ||
[[Category: Lu | [[Category: Grabarek Z]] | ||
[[Category: Shen | [[Category: Lu D]] | ||
[[Category: Soelaiman | [[Category: Shen Y-Q]] | ||
[[Category: Tang | [[Category: Soelaiman S]] | ||
[[Category: Yan | [[Category: Tang W-J]] | ||
[[Category: Yan S-Z]] | |||
Latest revision as of 10:45, 7 February 2024
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)
Structural highlights
FunctionCYAA_BACAN One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host. See Also |
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