1k8t: Difference between revisions

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-[[Image:1k8t.png|left|200px]]
-<!--
+==Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)==
-The line below this paragraph, containing "STRUCTURE_1k8t", creates the "Structure Box" on the page.
+<StructureSection load='1k8t' size='340' side='right'caption='[[1k8t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1k8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. The April 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Anthrax Toxin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_4 10.2210/rcsb_pdb/mom_2002_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8T FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1k8t|  PDB=1k8t  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8t OCA], [https://pdbe.org/1k8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8t RCSB], [https://www.ebi.ac.uk/pdbsum/1k8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
-'''Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)'''
+==See Also==
+*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]]
+__TOC__
-{{ABSTRACT_11807546}}
+</StructureSection>
-==About this Structure==
-K8T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. The following page contains interesting information on the relation of 1K8T with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb28_1.html Anthrax Toxin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8T OCA].
-[[Category: Adenylate cyclase]]
 [[Category: Anthrax Toxin]]
 [[Category: Bacillus anthracis]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bard, J.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Bohm, A.]]
+[[Category: Bard J]]
-[[Category: Drum, C L.]]
+[[Category: Bohm A]]
-[[Category: Grabarek, Z.]]
+[[Category: Drum CL]]
-[[Category: Lu, D.]]
+[[Category: Grabarek Z]]
-[[Category: Shen, Y Q.]]
+[[Category: Lu D]]
-[[Category: Soelaiman, S.]]
+[[Category: Shen Y-Q]]
-[[Category: Tang, W J.]]
+[[Category: Soelaiman S]]
-[[Category: Yan, S Z.]]
+[[Category: Tang W-J]]
-[[Category: Adenylyl cyclase]]
+[[Category: Yan S-Z]]
-[[Category: Anthrax]]
-[[Category: Calmodulin]]
-[[Category: Edema factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:37:51 2008''