1k8c: Difference between revisions

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[[Image:1k8c.png|left|200px]]


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==Crystal structure of dimeric xylose reductase in complex with NADP(H)==
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<StructureSection load='1k8c' size='340' side='right'caption='[[1k8c]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1k8c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yamadazyma_tenuis Yamadazyma tenuis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_1k8c|  PDB=1k8c  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8c OCA], [https://pdbe.org/1k8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8c RCSB], [https://www.ebi.ac.uk/pdbsum/1k8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8c ProSAT]</span></td></tr>
 
</table>
===Crystal structure of dimeric xylose reductase in complex with NADP(H)===
== Function ==
 
[https://www.uniprot.org/uniprot/XYL1_CANTE XYL1_CANTE] Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.
 
== Evolutionary Conservation ==
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==About this Structure==
  </jmolCheckbox>
1K8C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Candida_tenuis Candida tenuis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8C OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k8c ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis., Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK, Biochemistry. 2002 Jul 16;41(28):8785-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12102621 12102621]
</StructureSection>
[[Category: Aldehyde reductase]]
[[Category: Large Structures]]
[[Category: Candida tenuis]]
[[Category: Yamadazyma tenuis]]
[[Category: Single protein]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K L.]]
[[Category: Klimacek M]]
[[Category: Klimacek, M.]]
[[Category: Nidetzky B]]
[[Category: Nidetzky, B.]]
[[Category: Wilson DK]]
[[Category: Wilson, D K.]]
[[Category: Aldo-keto reductase]]
[[Category: Beta-alpha barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 09:56:10 2008''

Latest revision as of 10:44, 7 February 2024

Crystal structure of dimeric xylose reductase in complex with NADP(H)Crystal structure of dimeric xylose reductase in complex with NADP(H)

Structural highlights

1k8c is a 4 chain structure with sequence from Yamadazyma tenuis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

XYL1_CANTE Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1k8c, resolution 2.10Å

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