1k88: Difference between revisions

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-{{Seed}}
-[[Image:1k88.png|left|200px]]
-<!--
+==Crystal structure of procaspase-7==
-The line below this paragraph, containing "STRUCTURE_1k88", creates the "Structure Box" on the page.
+<StructureSection load='1k88' size='340' side='right'caption='[[1k88]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1k88]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Caspases''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_8 10.2210/rcsb_pdb/mom_2004_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K88 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k88 OCA], [https://pdbe.org/1k88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k88 RCSB], [https://www.ebi.ac.uk/pdbsum/1k88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k88 ProSAT]</span></td></tr>
-{{STRUCTURE_1k88|  PDB=1k88  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k88_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k88 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of procaspase-7===
+==See Also==
+*[[Caspase 3D structures|Caspase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_11701129}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11701129 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11701129}}
-==About this Structure==
-K88 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Additional information on 1K88 is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K88 OCA].
-==Reference==
-Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding., Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y, Cell. 2001 Nov 2;107(3):399-407. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11701129 11701129]
 [[Category: Caspases]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Alnemri, E S.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Chai, J.]]
+[[Category: Alnemri ES]]
-[[Category: Shi, Y.]]
+[[Category: Chai J]]
-[[Category: Shiozaki, E.]]
+[[Category: Shi Y]]
-[[Category: Srinivasa, S M.]]
+[[Category: Shiozaki E]]
-[[Category: Wu, Q.]]
+[[Category: Srinivasa SM]]
-[[Category: Apoptosis]]
+[[Category: Wu Q]]
-[[Category: Procaspase activation]]
-[[Category: Protease]]
-[[Category: Substrate binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:11:10 2008''