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[[Image:1k5j.png|left|200px]]


{{STRUCTURE_1k5j|  PDB=1k5j  |  SCENE=  }}
==The Crystal Structure of Nucleoplasmin-Core==
 
<StructureSection load='1k5j' size='340' side='right'caption='[[1k5j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===The Crystal Structure of Nucleoplasmin-Core===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1k5j]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The January 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Importins''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_1 10.2210/rcsb_pdb/mom_2007_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K5J FirstGlance]. <br>
{{ABSTRACT_PUBMED_11684019}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5j OCA], [https://pdbe.org/1k5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k5j RCSB], [https://www.ebi.ac.uk/pdbsum/1k5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k5j ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1k5j]] is a 5 chain structure of [[Nucleoplasmin]] with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The January 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Importins''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_1 10.2210/rcsb_pdb/mom_2007_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5J OCA].  
== Function ==
[https://www.uniprot.org/uniprot/NUPL_XENLA NUPL_XENLA] Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Nucleoplasmin is an acidic protein which is able to assemble nucleosomes by binding histones and transferring them to DNA.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/1k5j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k5j ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nucleoplasmin|Nucleoplasmin]]
*[[Nucleoplasmin|Nucleoplasmin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011684019</ref><references group="xtra"/>
[[Category: Importins]]
[[Category: Importins]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Akey, C W.]]
[[Category: Akey CW]]
[[Category: Akey, I V.]]
[[Category: Akey IV]]
[[Category: Dingwall, C.]]
[[Category: Dingwall C]]
[[Category: Dutta, S.]]
[[Category: Dutta S]]
[[Category: Hartman, K L.]]
[[Category: Hartman KL]]
[[Category: Head, J F.]]
[[Category: Head JF]]
[[Category: Laue, T.]]
[[Category: Laue T]]
[[Category: Nolte, R T.]]
[[Category: Nolte RT]]
[[Category: Beta-barrel]]
[[Category: Beta-bulge]]
[[Category: Chaperone]]
[[Category: Jellyroll]]
[[Category: Pentamer]]

Latest revision as of 10:44, 7 February 2024

The Crystal Structure of Nucleoplasmin-CoreThe Crystal Structure of Nucleoplasmin-Core

Structural highlights

1k5j is a 5 chain structure with sequence from Xenopus laevis. The January 2007 RCSB PDB Molecule of the Month feature on Importins by David S. Goodsell is 10.2210/rcsb_pdb/mom_2007_1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NUPL_XENLA Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Nucleoplasmin is an acidic protein which is able to assemble nucleosomes by binding histones and transferring them to DNA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1k5j, resolution 2.30Å

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