1jxb: Difference between revisions

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-{{Seed}}
-[[Image:1jxb.png|left|200px]]
-<!--
+==I53A, a point mutant of the cysteine-free variant of E. coli Rnase HI==
-The line below this paragraph, containing "STRUCTURE_1jxb", creates the "Structure Box" on the page.
+<StructureSection load='1jxb' size='340' side='right'caption='[[1jxb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1jxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxb OCA], [https://pdbe.org/1jxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxb RCSB], [https://www.ebi.ac.uk/pdbsum/1jxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxb ProSAT]</span></td></tr>
-{{STRUCTURE_1jxb|  PDB=1jxb  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RNH_ECOLI RNH_ECOLI] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxb ConSurf].
+<div style="clear:both"></div>
-===I53A, a point mutant of the cysteine-free variant of E. coli Rnase HI===
+==See Also==
+*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_11847275}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11847275 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11847275}}
-==About this Structure==
-JXB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXB OCA].
-==Reference==
-Propagation of a single destabilizing mutation throughout the Escherichia coli ribonuclease HI native state., Spudich G, Lorenz S, Marqusee S, Protein Sci. 2002 Mar;11(3):522-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11847275 11847275]
 [[Category: Escherichia coli]]
-[[Category: Ribonuclease H]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Lorenz S]]
-[[Category: Lorenz, S.]]
+[[Category: Marqusee S]]
-[[Category: Marqusee, S.]]
+[[Category: Spudich G]]
-[[Category: Spudich, G.]]
-[[Category: 4-helix bundle]]
-[[Category: Mixed alpha/beta]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:00:03 2008''