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==Crystal Structure of Murine Tcl1 at 2.5 Resolution==
==Crystal Structure of Murine Tcl1 at 2.5 Resolution==
<StructureSection load='1jnp' size='340' side='right' caption='[[1jnp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1jnp' size='340' side='right'caption='[[1jnp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jnp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNP FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnp OCA], [http://pdbe.org/1jnp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jnp RCSB], [http://www.ebi.ac.uk/pdbsum/1jnp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnp ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnp OCA], [https://pdbe.org/1jnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnp RCSB], [https://www.ebi.ac.uk/pdbsum/1jnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TCL1A_MOUSE TCL1A_MOUSE]] Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).  
[https://www.uniprot.org/uniprot/TCL1A_MOUSE TCL1A_MOUSE] Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnp ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnp ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family.,Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:11679718<ref>PMID:11679718</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1jnp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Croce, C M]]
[[Category: Mus musculus]]
[[Category: DuBois, G C]]
[[Category: Croce CM]]
[[Category: Harrison, R W]]
[[Category: DuBois GC]]
[[Category: Petock, J M]]
[[Category: Harrison RW]]
[[Category: Torshin, I Y]]
[[Category: Petock JM]]
[[Category: Wang, Y F]]
[[Category: Torshin IY]]
[[Category: Weber, I T]]
[[Category: Wang YF]]
[[Category: Beta barrel]]
[[Category: Weber IT]]
[[Category: Dimer]]
[[Category: Immune system]]

Latest revision as of 10:40, 7 February 2024

Crystal Structure of Murine Tcl1 at 2.5 ResolutionCrystal Structure of Murine Tcl1 at 2.5 Resolution

Structural highlights

1jnp is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TCL1A_MOUSE Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1jnp, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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