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[[Image:1jmv.gif|left|200px]]


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==Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution==
The line below this paragraph, containing "STRUCTURE_1jmv", creates the "Structure Box" on the page.
<StructureSection load='1jmv' size='340' side='right'caption='[[1jmv]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jmv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1jmv|  PDB=1jmv  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmv OCA], [https://pdbe.org/1jmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmv RCSB], [https://www.ebi.ac.uk/pdbsum/1jmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmv ProSAT]</span></td></tr>
 
</table>
'''Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution'''
== Function ==
 
[https://www.uniprot.org/uniprot/USPA_HAEIN USPA_HAEIN] Required for resistance to DNA-damaging agents (By similarity).
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
BACKGROUND: The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. However, neither the structure of UspA nor the biochemical mechanism by which it protects cells from the broad spectrum of stress agents is known. RESULTS: The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschi MJ0577 protein, a protein whose crystal structure revealed a novel ATP binding motif. UspA differs significantly from the MJ0577 structure in several details, including the triphosphate binding loop of the ATP binding motif; UspA shows no ATP binding activity. CONCLUSIONS: Within the universal stress protein family that is delineated by sequence similarity, UspA is the only member which has been correlated with a cellular activity, and MJ0577 is the only member which has been assigned a biochemical activity, i.e., ATP binding. UspA has a similar fold to the MJ0577 protein but does not bind ATP. This suggests that members of this protein family will segregate into two groups, based on whether or not they bind ATP. By implication, one subset of the universal stress proteins presumably has an ATP-dependent function, while another subset functions in ATP-independent activities.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmv_consurf.spt"</scriptWhenChecked>
1JMV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMV OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Structure of the universal stress protein of Haemophilus influenzae., Sousa MC, McKay DB, Structure. 2001 Dec;9(12):1135-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11738040 11738040]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmv ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: McKay, D B.]]
[[Category: McKay DB]]
[[Category: Sousa, M C.]]
[[Category: Sousa MC]]
[[Category: Universal stress protein]]
[[Category: Uspa]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:25:37 2008''

Latest revision as of 10:40, 7 February 2024

Structure of Haemophylus influenzae Universal Stress Protein At 1.85A ResolutionStructure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution

Structural highlights

1jmv is a 4 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

USPA_HAEIN Required for resistance to DNA-damaging agents (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1jmv, resolution 1.85Å

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