1jiz: Difference between revisions

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-[[Image:1jiz.png|left|200px]]
-<!--
+==Crystal Structure Analysis of human Macrophage Elastase MMP-12==
-The line below this paragraph, containing "STRUCTURE_1jiz", creates the "Structure Box" on the page.
+<StructureSection load='1jiz' size='340' side='right'caption='[[1jiz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1jiz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JIZ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGS:N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE+HYDROCHLORIDE'>CGS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1jiz|  PDB=1jiz  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jiz OCA], [https://pdbe.org/1jiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jiz RCSB], [https://www.ebi.ac.uk/pdbsum/1jiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jiz ProSAT]</span></td></tr>
+</table>
-===Crystal Structure Analysis of human Macrophage Elastase MMP-12===
+== Function ==
+[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_11575929}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 11575929 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1jiz_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_11575929}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[1jiz]] is a 2 chain structure of [[Elastase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIZ OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jiz ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Elastase]]
+*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:11575929</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Macrophage elastase]]
+[[Category: Large Structures]]
-[[Category: Bauer, M M.T.]]
+[[Category: Bauer MMT]]
-[[Category: Dollinger, H.]]
+[[Category: Dollinger H]]
-[[Category: Jung, B.]]
+[[Category: Jung B]]
-[[Category: Nar, H.]]
+[[Category: Nar H]]
-[[Category: Werle, K.]]
+[[Category: Werle K]]
-[[Category: Chronic obstructive pulmonary disease]]
-[[Category: Hydrolase]]
-[[Category: Matrix metalloproteinase]]
-[[Category: Mmp-12]]