1jgg: Difference between revisions

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[[Image:1jgg.gif|left|200px]]


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==Even-skipped Homeodomain Complexed to AT-rich DNA==
The line below this paragraph, containing "STRUCTURE_1jgg", creates the "Structure Box" on the page.
<StructureSection load='1jgg' size='340' side='right'caption='[[1jgg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jgg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgg OCA], [https://pdbe.org/1jgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgg RCSB], [https://www.ebi.ac.uk/pdbsum/1jgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgg ProSAT]</span></td></tr>
{{STRUCTURE_1jgg|  PDB=1jgg  |  SCENE= }}
</table>
 
== Function ==
'''Even-skipped Homeodomain Complexed to AT-rich DNA'''
[https://www.uniprot.org/uniprot/EVE_DROME EVE_DROME] May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
even-skipped is a homeobox gene important in controlling segment patterning in the embryonic fruit fly. Its homeobox encodes a DNA binding domain which binds with similar affinities to two DNA consensus sequences, one AT-rich, the other GC-rich. We describe a crystallographic analysis of the Even-skipped homeodomain complexed to an AT-rich oligonucleotide at 2.0 A resolution. The structure reveals a novel arrangement of two homeodomains bound to one 10 bp DNA sequence in a tandem fashion. This arrangement suggests a mechanism for the homeoproteins' regulatory specificity. In addition, the functionally important residue Gln50 is observed in multiple conformations making direct and water-mediated hydrogen bonds with the DNA bases.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgg_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1JGG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGG OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgg ConSurf].
Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity., Hirsch JA, Aggarwal AK, EMBO J. 1995 Dec 15;14(24):6280-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8557047 8557047]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Aggarwal, A K.]]
[[Category: Aggarwal AK]]
[[Category: Hirsch, J A.]]
[[Category: Hirsch JA]]
[[Category: Even-skipped]]
[[Category: Homeodomain]]
[[Category: Protein-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:11:37 2008''

Latest revision as of 10:39, 7 February 2024

Even-skipped Homeodomain Complexed to AT-rich DNAEven-skipped Homeodomain Complexed to AT-rich DNA

Structural highlights

1jgg is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EVE_DROME May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1jgg, resolution 2.00Å

Drag the structure with the mouse to rotate

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OCA
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