1in0: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1in0.jpg|left|200px]]<br /><applet load="1in0" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1in0, resolution 2.14&Aring;" />
-'''YAJQ PROTEIN (HI1034)'''<br />
-==Overview==
+==YAJQ PROTEIN (HI1034)==
-A hypothetical protein encoded by the gene YajQ of Haemophilus influenzae, was selected, as part of a structural genomics project, for X-ray, crystallographic structure determination and analysis to assist with the, functional assignment. The protein is present in most bacteria, but not in, archaea or eukaryotes. The amino acid sequence has no homology to that of, other proteins. The YajQ protein was cloned, expressed, and the crystal, structure determined at 2.1-A resolution by applying the multiwavelength, anomalous dispersion method to a mercury derivative. The polypeptide chain, is folded into two domains with identical folding topology. Each domain, has a four-stranded antiparallel beta-sheet flanked on one side by two, alpha-helices. This structural motif is a characteristic feature of many, RNA-binding proteins. The tetrameric structure observed in the crystal, suggests a possibility of binding two stretches of double-stranded nucleic, acid.
+<StructureSection load='1in0' size='340' side='right'caption='[[1in0]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1in0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IN0 FirstGlance]. <br>
-IN0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae] with HG, NA and MMC as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IN0 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1in0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in0 OCA], [https://pdbe.org/1in0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1in0 RCSB], [https://www.ebi.ac.uk/pdbsum/1in0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1in0 ProSAT]</span></td></tr>
-Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains., Teplyakov A, Obmolova G, Bir N, Reddy P, Howard AJ, Gilliland GL, J Struct Funct Genomics. 2003;4(1):1-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12943362 12943362]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Y1034_HAEIN Y1034_HAEIN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/1in0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1in0 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Haemophilus influenzae]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Gilliland, G.L.]]
+[[Category: Gilliland GL]]
-[[Category: S2F, Structure.2.Function.Project.]]
+[[Category: Teplyakov A]]
-[[Category: Teplyakov, A.]]
-[[Category: HG]]
-[[Category: MMC]]
-[[Category: NA]]
-[[Category: alpha and beta sandwich]]
-[[Category: s2f]]
-[[Category: structural genomics]]
-[[Category: structure 2 function project]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:30:44 2007''