1in0: Difference between revisions

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-[[Image:1in0.jpg|left|200px]]
-<!--
+==YAJQ PROTEIN (HI1034)==
-The line below this paragraph, containing "STRUCTURE_1in0", creates the "Structure Box" on the page.
+<StructureSection load='1in0' size='340' side='right'caption='[[1in0]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1in0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IN0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-{{STRUCTURE_1in0|  PDB=1in0  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1in0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in0 OCA], [https://pdbe.org/1in0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1in0 RCSB], [https://www.ebi.ac.uk/pdbsum/1in0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1in0 ProSAT]</span></td></tr>
+</table>
-'''YAJQ PROTEIN (HI1034)'''
+== Function ==
+[https://www.uniprot.org/uniprot/Y1034_HAEIN Y1034_HAEIN]
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
-A hypothetical protein encoded by the gene YajQ of Haemophilus influenzae was selected, as part of a structural genomics project, for X-ray crystallographic structure determination and analysis to assist with the functional assignment. The protein is present in most bacteria, but not in archaea or eukaryotes. The amino acid sequence has no homology to that of other proteins. The YajQ protein was cloned, expressed, and the crystal structure determined at 2.1-A resolution by applying the multiwavelength anomalous dispersion method to a mercury derivative. The polypeptide chain is folded into two domains with identical folding topology. Each domain has a four-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This structural motif is a characteristic feature of many RNA-binding proteins. The tetrameric structure observed in the crystal suggests a possibility of binding two stretches of double-stranded nucleic acid.
+Check<jmol>
+  <jmolCheckbox>
-==About this Structure==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/1in0_consurf.spt"</scriptWhenChecked>
-IN0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN0 OCA].
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==Reference==
+  </jmolCheckbox>
-Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains., Teplyakov A, Obmolova G, Bir N, Reddy P, Howard AJ, Gilliland GL, J Struct Funct Genomics. 2003;4(1):1-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12943362 12943362]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1in0 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Haemophilus influenzae]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Gilliland, G L.]]
+[[Category: Gilliland GL]]
-[[Category: S2F, Structure 2.Function Project.]]
+[[Category: Teplyakov A]]
-[[Category: Teplyakov, A.]]
-[[Category: Alpha and beta sandwich]]
-[[Category: S2f]]
-[[Category: Structural genomic]]
-[[Category: Structure 2 function project]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:10:28 2008''