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==Multi-Conformation Crystal Structure of GGm5CGCC==
==Multi-Conformation Crystal Structure of GGm5CGCC==
<StructureSection load='1ih4' size='340' side='right' caption='[[1ih4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1ih4' size='340' side='right'caption='[[1ih4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ih4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IH4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ih4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IH4 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ih1|1ih1]], [[1ih2|1ih2]], [[1ih3|1ih3]], [[1ih6|1ih6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ih4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih4 OCA], [http://pdbe.org/1ih4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ih4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ih4 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ih4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih4 OCA], [https://pdbe.org/1ih4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ih4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ih4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ih4 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
A crystallographic map of the transition from B-DNA to A-DNA.,Vargason JM, Henderson K, Ho PS Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969<ref>PMID:11390969</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ih4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Henderson, K]]
[[Category: Large Structures]]
[[Category: Ho, P S]]
[[Category: Henderson K]]
[[Category: Vargason, J M]]
[[Category: Ho PS]]
[[Category: B to a dna transition]]
[[Category: Vargason JM]]
[[Category: Dna]]
[[Category: Dna transition]]
[[Category: Structural transition]]

Latest revision as of 10:35, 7 February 2024

Multi-Conformation Crystal Structure of GGm5CGCCMulti-Conformation Crystal Structure of GGm5CGCC

Structural highlights

1ih4 is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1ih4, resolution 1.90Å

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