1ig3: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1ig3.png|left|200px]]


{{STRUCTURE_1ig3|  PDB=1ig3  |  SCENE=  }}
==Mouse Thiamin Pyrophosphokinase Complexed with Thiamin==
 
<StructureSection load='1ig3' size='340' side='right'caption='[[1ig3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Mouse Thiamin Pyrophosphokinase Complexed with Thiamin===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ig3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IG3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11419946}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ig3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig3 OCA], [https://pdbe.org/1ig3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ig3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ig3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ig3 ProSAT]</span></td></tr>
[[1ig3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG3 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/TPK1_MOUSE TPK1_MOUSE] Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.<ref>PMID:10567383</ref> <ref>PMID:16365036</ref>
<ref group="xtra">PMID:011419946</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/1ig3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ig3 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Thiamine diphosphokinase]]
[[Category: Baker L-J]]
[[Category: Baker, L J.]]
[[Category: Harris RA]]
[[Category: Harris, R A.]]
[[Category: Liu J]]
[[Category: Liu, J.]]
[[Category: Timm DE]]
[[Category: Timm, D E.]]
[[Category: Alpha/beta/alpha sandwich]]
[[Category: Beta barrel]]
[[Category: Transferase]]

Latest revision as of 10:35, 7 February 2024

Mouse Thiamin Pyrophosphokinase Complexed with ThiaminMouse Thiamin Pyrophosphokinase Complexed with Thiamin

Structural highlights

1ig3 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TPK1_MOUSE Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Nosaka K, Onozuka M, Nishino H, Nishimura H, Kawasaki Y, Ueyama H. Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. J Biol Chem. 1999 Nov 26;274(48):34129-33. PMID:10567383
  2. ↑ Liu JY, Timm DE, Hurley TD. Pyrithiamine as a substrate for thiamine pyrophosphokinase. J Biol Chem. 2006 Mar 10;281(10):6601-7. Epub 2005 Dec 19. PMID:16365036 doi:10.1074/jbc.M510951200

1ig3, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1ig3&oldid=4044951"