1ieg: Difference between revisions

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-[[Image:1ieg.png|left|200px]]
-{{STRUCTURE_1ieg|  PDB=1ieg  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A/H157A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE==
+<StructureSection load='1ieg' size='340' side='right'caption='[[1ieg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ieg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ieg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieg OCA], [https://pdbe.org/1ieg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ieg RCSB], [https://www.ebi.ac.uk/pdbsum/1ieg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SCAF_HCMVA SCAF_HCMVA] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity).  Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity).  Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/1ieg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ieg ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A/H157A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE===
+==See Also==
+*[[Virus protease 3D structures|Virus protease 3D structures]]
-{{ABSTRACT_PUBMED_11371196}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Human herpesvirus 5 strain AD169]]
-[[1ieg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEG OCA].
+[[Category: Large Structures]]
+[[Category: Batra R]]
-==Reference==
+[[Category: Khayat R]]
-<ref group="xtra">PMID:011371196</ref><references group="xtra"/>
+[[Category: Lagace L]]
-[[Category: Assemblin]]
+[[Category: Massariol MJ]]
-[[Category: Human herpesvirus 5]]
+[[Category: Tong L]]
-[[Category: Batra, R.]]
-[[Category: Khayat, R.]]
-[[Category: Lagace, L.]]
-[[Category: Massariol, M J.]]
-[[Category: Tong, L.]]
-[[Category: Catalytic triad]]
-[[Category: Coat protein]]
-[[Category: Hydrolase]]
-[[Category: Serine protease]]
-[[Category: Viral protease]]