1ido: Difference between revisions

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-[[Image:1ido.gif|left|200px]]<br />
-<applet load="1ido" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1ido, resolution 1.7&Aring;" />
-'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''<br />
-==Overview==
+==I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND==
-We have determined the high resolution crystal structure of the A domain, from the alpha chain of integrin CR3. The domain adopts a classic, alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site, at its surface. One of the coordinating ligands is the glutamate side, chain from another A domain molecule. We suggest that this site represents, a general metal ion-dependent adhesion site (MIDAS) for binding protein, ligands. We further propose that the beta subunits of integrins contain a, MIDAS motif within a modified A domain. Our crystal structure will allow, reliable models to be built for other members of the A domain superfamily, and should facilitate development of novel adhesion modulatory drugs.
+<StructureSection load='1ido' size='340' side='right'caption='[[1ido]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ido]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IDO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ido OCA], [https://pdbe.org/1ido PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ido RCSB], [https://www.ebi.ac.uk/pdbsum/1ido PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ido ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
+== Function ==
+[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/1ido_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ido ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-IDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: MG. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA].
+*[[Integrin 3D structures|Integrin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7867070 7867070]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Lee, J.O.]]
+[[Category: Lee J-O]]
-[[Category: Liddington, R.]]
+[[Category: Liddington R]]
-[[Category: MG]]
-[[Category: cell adhesion protein]]
-[[Category: cytoskeleton]]
-[[Category: extracellular matrix]]
-[[Category: glycoprotein]]
-[[Category: integrin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:29:00 2007''