1id1: Difference between revisions

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-[[Image:1id1.jpg|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL==
-The line below this paragraph, containing "STRUCTURE_1id1", creates the "Structure Box" on the page.
+<StructureSection load='1id1' size='340' side='right'caption='[[1id1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1id1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ID1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1id1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1id1 OCA], [https://pdbe.org/1id1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1id1 RCSB], [https://www.ebi.ac.uk/pdbsum/1id1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1id1 ProSAT]</span></td></tr>
-{{STRUCTURE_1id1|  PDB=1id1  |  SCENE=  }}
+</table>
+== Function ==
-'''CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL'''
+[https://www.uniprot.org/uniprot/KCH_ECOLI KCH_ECOLI] K(+)-specific ion channel. May play a role in the defense against osmotic shock.<ref>PMID:8170937</ref> <ref>PMID:12912904</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==Overview==
+Check<jmol>
-The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K+ transporters and K+ channels. The RCK domain has a Rossmann-fold topology with unique positions, not commonly conserved among Rossmann-fold proteins, composing a well-conserved salt bridge and a hydrophobic dimer interface. Structure-based amino acid sequence alignments and mutational analysis are used to demonstrate that an RCK domain is also present and is an important component of the gating machinery in eukaryotic large-conductance Ca2+ activated K+ channels.
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/1id1_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-ID1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==Reference==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1id1 ConSurf].
-Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel., Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R, Neuron. 2001 Mar;29(3):593-601. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11301020 11301020]
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Cadene, M.]]
+[[Category: Cadene M]]
-[[Category: Chait, B T.]]
+[[Category: Chait BT]]
-[[Category: Jiang, Y.]]
+[[Category: Jiang Y]]
-[[Category: MacKinnon, R.]]
+[[Category: MacKinnon R]]
-[[Category: Pico, A.]]
+[[Category: Pico A]]
-[[Category: Bk channel]]
-[[Category: E coli potassium channel]]
-[[Category: Rck domain]]
-[[Category: Rossmann fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:51:40 2008''