1ic2: Difference between revisions

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[[Image:1ic2.png|left|200px]]


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==DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE==
The line below this paragraph, containing "STRUCTURE_1ic2", creates the "Structure Box" on the page.
<StructureSection load='1ic2' size='340' side='right'caption='[[1ic2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ic2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IC2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ic2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic2 OCA], [https://pdbe.org/1ic2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ic2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ic2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic2 ProSAT]</span></td></tr>
{{STRUCTURE_1ic2| PDB=1ic2 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPM1_CHICK TPM1_CHICK] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/1ic2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ic2 ConSurf].
<div style="clear:both"></div>


===DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE===
==See Also==
 
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
 
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{{ABSTRACT_PUBMED_11438684}}
 
==About this Structure==
1IC2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC2 OCA].
 
==Reference==
Deciphering the design of the tropomyosin molecule., Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C, Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8496-501. Epub 2001 Jul 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11438684 11438684]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Brown, J H.]]
[[Category: Brown JH]]
[[Category: Cohen, C.]]
[[Category: Cohen C]]
[[Category: Dominguez, R.]]
[[Category: Dominguez R]]
[[Category: Greenfield, N J.]]
[[Category: Greenfield NJ]]
[[Category: Hitchcock-DeGregori, S E.]]
[[Category: Hitchcock-DeGregori SE]]
[[Category: Jun, G.]]
[[Category: Jun G]]
[[Category: Kim, K H.]]
[[Category: Kim K-H]]
[[Category: Volkmann, N.]]
[[Category: Volkmann N]]
[[Category: Alanine]]
[[Category: Alpha-helical coiled coil]]
[[Category: Axial stagger]]
[[Category: Bend]]
[[Category: Symmetry]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:44:34 2008''

Latest revision as of 10:33, 7 February 2024

DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULEDECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE

Structural highlights

1ic2 is a 4 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TPM1_CHICK Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ic2, resolution 2.00Å

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