1hy3: Difference between revisions

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-[[Image:1hy3.png|left|200px]]
-{{STRUCTURE_1hy3|  PDB=1hy3  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF HUMAN ESTROGEN SULFOTRANSFERASE V269E MUTANT IN THE PRESENCE OF PAPS==
+<StructureSection load='1hy3' size='340' side='right'caption='[[1hy3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF HUMAN ESTROGEN SULFOTRANSFERASE V269E MUTANT IN THE PRESENCE OF PAPS===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1hy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HY3 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11884392}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PPS:3-PHOSPHATE-ADENOSINE-5-PHOSPHATE+SULFATE'>PPS</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hy3 OCA], [https://pdbe.org/1hy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hy3 RCSB], [https://www.ebi.ac.uk/pdbsum/1hy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hy3 ProSAT]</span></td></tr>
-[[1hy3]] is a 2 chain structure of [[Sulfotransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY3 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ST1E1_HUMAN ST1E1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.<ref>PMID:11884392</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hy3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hy3 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Sulfotransferase|Sulfotransferase]]
+*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:011884392</ref><references group="xtra"/>
+<references/>
-[[Category: Estrone sulfotransferase]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Negishi, M.]]
+[[Category: Large Structures]]
-[[Category: Pedersen, L C.]]
+[[Category: Negishi M]]
-[[Category: Petrochenko, E V.]]
+[[Category: Pedersen LC]]
-[[Category: Shevtsov, S.]]
+[[Category: Petrochenko EV]]
-[[Category: Estrogen]]
+[[Category: Shevtsov S]]
-[[Category: Human]]
-[[Category: Pap]]
-[[Category: Sulfotransferase]]
-[[Category: Transferase]]