1hy0: Difference between revisions

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[[Image:1hy0.png|left|200px]]


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==CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)==
The line below this paragraph, containing "STRUCTURE_1hy0", creates the "Structure Box" on the page.
<StructureSection load='1hy0' size='340' side='right'caption='[[1hy0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hy0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HY0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1hy0| PDB=1hy0 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hy0 OCA], [https://pdbe.org/1hy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hy0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hy0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARLY1_ANAPL ARLY1_ANAPL] Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase.<ref>PMID:7944404</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hy0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hy0 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)===
==See Also==
 
*[[Crystallin 3D structures|Crystallin 3D structures]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 11258884 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11258884}}
 
==About this Structure==
1HY0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY0 OCA].
 
==Reference==
Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis., Sampaleanu LM, Vallee F, Slingsby C, Howell PL, Biochemistry. 2001 Mar 6;40(9):2732-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11258884 11258884]
[[Category: Anas platyrhynchos]]
[[Category: Anas platyrhynchos]]
[[Category: Argininosuccinate lyase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Howell PL]]
[[Category: Howell, P L.]]
[[Category: Sampaleanu LM]]
[[Category: Sampaleanu, L M.]]
[[Category: Slingsby C]]
[[Category: Slingsby, C.]]
[[Category: Vallee F]]
[[Category: Vallee, F.]]
[[Category: Argininosuccinate lyase]]
[[Category: Delta 1 crystallin]]
[[Category: Eye lens protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:06:36 2008''

Latest revision as of 10:31, 7 February 2024

CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)

Structural highlights

1hy0 is a 2 chain structure with sequence from Anas platyrhynchos. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARLY1_ANAPL Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Lee HJ, Lin CC, Chiou SH, Chang GG. Characterization of the multiple forms of duck lens delta-crystallin with endogenous argininosuccinate lyase activity. Arch Biochem Biophys. 1994 Oct;314(1):31-8. PMID:7944404 doi:http://dx.doi.org/10.1006/abbi.1994.1408

1hy0, resolution 2.20Å

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