1hti: Difference between revisions

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-[[Image:1hti.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF RECOMBINANT HUMAN TRIOSEPHOSPHATE ISOMERASE AT 2.8 ANGSTROMS RESOLUTION. TRIOSEPHOSPHATE ISOMERASE RELATED HUMAN GENETIC DISORDERS AND COMPARISON WITH THE TRYPANOSOMAL ENZYME==
-The line below this paragraph, containing "STRUCTURE_1hti", creates the "Structure Box" on the page.
+<StructureSection load='1hti' size='340' side='right'caption='[[1hti]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1hti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
-{{STRUCTURE_1hti|  PDB=1hti  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hti OCA], [https://pdbe.org/1hti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hti RCSB], [https://www.ebi.ac.uk/pdbsum/1hti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hti ProSAT]</span></td></tr>
+</table>
-===CRYSTAL STRUCTURE OF RECOMBINANT HUMAN TRIOSEPHOSPHATE ISOMERASE AT 2.8 ANGSTROMS RESOLUTION. TRIOSEPHOSPHATE ISOMERASE RELATED HUMAN GENETIC DISORDERS AND COMPARISON WITH THE TRYPANOSOMAL ENZYME===
+== Disease ==
+[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]
-The line below this paragraph, {{ABSTRACT_PUBMED_8061610}}, adds the Publication Abstract to the page
+== Evolutionary Conservation ==
-(as it appears on PubMed at http://www.pubmed.gov), where 8061610 is the PubMed ID number.
+[[Image:Consurf_key_small.gif|200px|right]]
--->
+Check<jmol>
-{{ABSTRACT_PUBMED_8061610}}
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/1hti_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[1hti]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTI OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hti ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
+*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:008061610</ref><ref group="xtra">PMID:009285490</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Triose-phosphate isomerase]]
+[[Category: Large Structures]]
-[[Category: Hol, W G.J.]]
+[[Category: Hol WGJ]]
-[[Category: Mande, S C.]]
+[[Category: Mande SC]]